60 96
Table 5 – Risk factors for predicting on all-cause mortality following radical nephroureterectomy in 394 patients
Univariate analyses
Multivariate analyses
Base model
Base model
plus NLR
Base model plus
plasma fibrinogen
Base model plus
serum CRP
Base model
plus CMS
HR (95% CI);
p
HR (95% CI);
p
HR (95% CI);
p
HR (95% CI);
p
HR (95% CI);
p
HR (95% CI);
p
Age at RNU (
>
70 vs 70yr)
1.94 (1.28–2.83); 0.001 1.70 (1.14–2.52); 0.009 1.62 (1.09–2.41); 0.018 1.69 (1.14–2.51); 0.009 1.73 (1.16–2.57); 0.007 1.60 (1.07–2.38); 0.021
Sex (male vs female)
1.36 (0.89–2.08); 0.157
Tumor location (renal pelvis vs ureter)
0.83 (0.56–1.23); 0.359
Tumor grade (G3 vs G1/2)
2.30 (1.41–3.75); 0.001
Pathologic T stage,
p
for trend
<
0.001
0.001
0.002
0.001
<
0.001
<
0.001
pT2 vs pTa/1
2.56 (1.06–6.16); 0.036 2.06 (0.84–5.03); 0.115 1.95 (0.80–4.77); 0.141 2.11 (0.86–5.19); 0.102 2.04 (0.83–5.00); 0.119 2.44 (0.99–6.03); 0.054
pT3/4 vs pTa/1
6.05 (3.13–11.7);
<
0.001 3.85 (1.86–7.99);
<
0.001 3.60 (1.72–7.52); 0.001 3.72 (1.79–7.73);
<
0.001 4.20 (2.00–8.80);
<
0.001 4.53 (2.12–9.64);
<
0.001
Lymphovascular invasion
(positive vs negative)
3.53 (2.32–5.36);
<
0.001 1.96 (1.23–3.13); 0.005 1.96 (1.22–3.17); 0.006 1.95 (1.22–3.12); 0.006 1.66 (1.02–2.71); 0.042 1.67 (1.01–2.74); 0.044
Concomitant carcinoma in situ
(positive vs negative)
0.76 (0.45–1.28); 0.303
Adjuvant chemotherapy (yes vs no)
1.78 (1.18–2.70); 0.006
NLR (elevated vs not elevated)
2.09 (1.40–3.12);
<
0.001 –
1.77 (1.18–2.66); 0.006 –
–
–
Plasma fibrinogen (elevated vs not elevated)
1.88 (1.27–2.79); 0.002 –
–
1.66 (1.12–2.46); 0.011 –
–
Serum CRP (elevated vs not elevated)
2.33 (1.56–3.48);
<
0.001 –
–
–
2.13 (1.41–3.21);
<
0.001 –
CMS,
p
for trend
<
0.001
<
0.001
1 vs 0
1.20 (0.72–2.00); 0.477 –
–
–
–
0.99 (0.59–1.65); 0.959
2 vs 0
1.92 (1.10–3.36); 0.022 –
–
–
–
1.46 (0.83–2.57); 0.192
3 vs 0
4.18 (2.46–7.13);
<
0.001 –
–
–
–
3.80 (2.22–6.52);
<
0.001
Predictive accuracy, %
–
73.0
75.1
74.3
75.5
77.0
Mantel-Haenszel test
*–
–
0.007
0.012
0.001
<
0.001
CI = confidence interval; CMS = cumulative marker score; CRP = C-reactive protein; HR = hazard ratio; NLR = neutrophil-to-lymphocyte ratio; RNU = radical nephroureterectomy.
*
Compared with base model.
E U R O P E A N
U R O L O G Y
F O C U S
1
( 2 0 1 5
)
5 4 – 6 3
60