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including

the United

Kingdom

[53]

. High

smoking-related

morbidity

and mortality

are

expected

for

at

least

several

decades more

in

the European countries

that now have high

smoking

prevalence.

3.2.5.

Oceania

Two

of

the wealthiest

countries

in

Oceania,

Australia

and

New

Zealand,

have

been

quite

successful

in

reducing

smoking

prevalence

in

both men

and women,

from

>

30%

in

the 1980s

to

<

18%

in 2013

in men and women combined

[15,54]

.

However,

similar

to

the

smoking

pattern

in

Southeast Asia,

the male

smoking prevalence

in most

other

countries

on

this

continent

(eg,

Papua–New

Guinea

and

Tonga)

is high

( Table 1

).

3.3.

Blond

and

black

(dark)

tobacco

Blond

tobacco

is

flue-cured

tobacco

that

is

high

in

sugar

and

produces

a milder, more

inhalable

smoke

compared

with

black

(dark)

tobacco.

More

than

90%

of

cigarettes

smoked

globally

in

2013

were

Virginia

or

American

blended

cigarettes

[55] ,

both

of which

are

blond

tobacco.

Black

tobacco

is

chiefly

smoked

in

Latin

America,

Spain,

and

France

[56]

and

is

processed with

open-air

curing

or

air

curing

in

barns with

no

or

limited

artificial

heat.

The

strong

varieties

are

usually

used

to

make

cigars,

while

light

varieties

are

used

in

some

cigarette

blends

in

the

countries

above. With

blond

tobacco

being more

popular

among

smokers

globally,

black

tobacco

use

is

decreasing

[57]

.

For

example,

the

share

of

black

tobacco

in

the

tobacco market

in

Peru

decreased

from

17.6%

in

2000

to

1.5%

in

2009;

the

respective

decrease

in

Spain was

from

23.5%

to

9.2%

[57] .

The

few

laboratory

studies

that

exist

on

potentially

carcinogenic

compounds

in

black

and

blond

tobacco

and

their

effects

on

the

human

body

have

shown

higher

concentrations

of

N-nitrosamine

and

2-napthylamine

in

black tobacco and higher urine mutagenicity and blood DNA

adduct

levels

in

black

tobacco

smokers

[56,58]

.

However,

the

clinical

significance

of

these

differences

is

unclear.

3.4.

Tobacco

products

other

than

cigarettes

Cigarettes

are

the most

common

smoking

product world-

wide.

However,

there

are

other

tobacco

products

that

are

relatively

commonly used

in

some populations. Water pipe

(hookah)

smoking

has

traditionally

been

common

in

the

Middle East and North Africa and

in some parts of Southeast

Asia

[59]

.

Water

pipe

use

has

increased

among

young

people,

particularly

college

students,

in

Europe

and North

America

[59,60]

.

In

the United States,

for example, 7–20% of

college

students

[61]

and 5.4%

of high

school

students

[62]

reported

past-year/current water

pipe

use.

The

use

of

bidi

(tobacco

flakes wrapped

in

a

leaf

of

the

tendu

or

temburni

tree),

a

relatively

inexpensive

tobacco

product,

is

common

in

South

Asia,

in

particular

in

low-income

groups

[5] .

In

India,

bidi

is

the most

commonly

used

smoking

product

(prevalence:

9.2%),

followed

by

cigarettes

(5.7%),

water

pipes

(0.9%),

and

other

products

(1%)

[5] .

Global

consumption

of

roll-your-own

(RYO)

tobacco

increased

by

45%

from

2000

to

2013,

with

approximately

101

billion

RYO

cigarettes

smoked

worldwide

in

2013

(compared with nearly 6

trillion

regular cigarettes). Approxi-

mately

86%

of

RYO

cigarettes were

smoked

in

the

European

Union, where RYO cigarettes were much cheaper

than regular

cigarettes

[63] .

Global

consumption of

cigars and

cigarillos

(a

cigarillo

is

a

smaller,

narrower

version

of

a

cigar)

has

not

changed

since

the

late 2000s

and

is

approximately 24 billion

per

year,

nearly

half

of

which

are

smoked

in

the

United

States

[63] .

All

smoking

tobacco products

are

included

in

the

smoking

rates

shown

in

this

article, unless

stated

otherwise.

Smokeless

tobacco use

is

common

in South Asia, Central

Asia,

the

Nordic

countries,

and

Africa

(Supplementary

Table

1).

For

example,

smokeless

tobacco

use

in

India

is

more

common

than

smoking:

32.9%

of

men

and

18.4%

women

are

smokeless

tobacco

users

[5]

.

Among

children

aged

13–15

yr

in

South Asia, Central Asia,

the Middle

East,

and Africa,

the use of

tobacco products other

than cigarettes

is more

common

than

cigarette

smoking

[5]

.

3.5.

E-cigarettes

3.5.1.

What

is

an

e-cigarette?

Electronic

cigarettes

(e-cigarettes),

also

called

electronic

nicotine

delivery

systems

(ENDS)

,

are

battery-powered

devices

that

vaporize

a

liquid

solution

called

e-liquid

using

a

heating

element

known

as

an

atomizer

[64] .

E-liquid

generally

contains

nicotine,

propylene

glycol,

vegetable

glycerin,

and

various

additives

[64]

.

E-cigarette

smokers

inhale

the

resulting

aerosol,

which

some

say

gives

the

feeling of cigarette smoking. E-cigarettes are produced with

various

features

(eg, nonrefillable or

refillable), but many of

these

products

resemble

cigarettes.

As

e-cigarettes

do

not

include

combustion,

their

potential

to

deliver

nicotine

to

users

in

a

safer way

than

regular

cigarettes

and

to

aid

tobacco

smokers

in

quitting

are of high

interest; however, significantlymore research

is

necessary

to

evaluate

this potential

rigorously. While

two

randomized

controlled

clinical

trials

have

shown modest

effectiveness

of

e-cigarettes

in

helping

smokers

to

quit

[65,66]

,

two

longitudinal epidemiological

studies have not

shown

such

a

benefit

at

the

population

level

[64]

or

in

cancer patients

[67]

.

In addition

to research on e-cigarettes

as a smoking cessation

tool,

there

is a crucial need

for more

analysis

on

the

long-term health

effects

of

e-cigarette use

[64]

,

particularly

because

propylene

glycol

and

other

compounds

in

e-liquids may

expose

e-cigarette

users

to

increased

levels of

toxic chemicals

[68,69]

. Also, nicotine

is

an

addictive

substance,

and

e-cigarette

initiation

by

nonsmokers

may

eventually

lead

to

their

taking

up

traditional

cigarettes

[70] .

For

these

reasons,

regulations

have

been

recommended

by

some

health

authorities

to

reduce

the

initiation of e-cigarette smoking

in nonsmokers

(see

section

3.7,

Regulating

e-cigarettes

).

3.5.2.

Prevalence

of

use

As

e-cigarettes

have

been

marketed

only

recently,

their

prevalence

of

use

is

generally much

lower

than

cigarette

E U R O P E A N

U R O L O G Y

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