Segal et al. (2012)
1995-2005 278 72.8 T1 100
HG 100
Re-TUR NR;
BCG 35.6;
Chemo NR
36
-
-
HR=1.15,
p
=0.51
-
-
-
-
-
Rink et al. (2013)
1987-2007 2043 67
Ta 61.0;
T1 39.0
G1 23.6;
G2 33.8;
G3 42.6
Re-TUR NR;
BCG 16.1;
Chemo 3.8
49
HR=1.12
(0.94-1.34);
*HR=1.22
(1.01-1.48)
y
HR=0.43
(0.30-0.60)
;
zzzz
HR=0.91
(0.77-1.07);
§§§§
HR=0.35
(0.26-0.47)
kkkk
HR=1.29
(0.79-2.09);
*HR=2.09
(1.29-3.39)
y
HR=0.12
(0.03-0.44)
;
zzzz
HR=0.43
(0.29-0.63)
;
§§§§
HR=0.05
(0.01-0.19)
kkkk
-
-
HR=1.10
(0.86-1.41);
*HR=1.12
(0.85-1.47)
y
HR=0.81
(0.51-1.27);
zzzz
HR=0.67
(0.52-0.85)
;
§§§§
HR=0.54
(0.37-0.80)
kkkkSerretta et al. (2013)
2002-2003 395 68
Ta 36.5;
T1 63.5
G1 35.9;
G2 64.1
Re-TUR NR;
BCG NR;
Chemo 100
48
HR=1.60,
p
=0.04
-
-
-
-
-
-
-
Grotenhuis et al. (2014) 1995-2012 963 64
Ta 70.0;
Tis 3.8
T1 26.2
LG 61.8;
HG 38.2
Re-TUR NR;
BCG 22.0
Chemo 33.0
44
HR=1.06,
p
=0.68;
p
=0.47
z
p
=0.62
*** ;p
=0.61
yyy
HR=1.85,
p
=0.25;
p
=0.54
z
p
=0.95
*** ;p
=0.15
yyy
-
-
-
-
Kashif Khan et al. (2014) 2008-2012 64 59.9 NR
NR
Re-TUR NR;
BCG 100;
Chemo NR
28.4 NS
-
OR=4.02,
p
=0.04
-
-
-
-
-
Rausch et al. (2014)
1996-2006 192 68.3 Ta 76.3;
T1 23.7
G1 43.5;
G2 50.0;
G3 6.5
Re-TUR NR;
BCG NR;
Chemo NR
80
OR=1.40,
p
=0.11
-
OR=0.51,
p
=0.20
-
-
-
-
-
Wyszynski et al. (2014) 1994-2001 726 NR
Ta/T1 93.7;
Tis 6.3
LG 73.1;
HG 25.9
Re-TUR NR;
BCG NR;
Chemo NR
67.2
HR=1.61,
p
=0.003
; *HR=1.51,
p
=0.02
y
-
-
-
-
-
-
-
G1=grade 1; G2=grade 2; G3=grade 3; re-TUR=repeat transurethral resection of the bladder; NR=not reported; BCG=bacillus Calmette-Gue´rin; chemo=adjuvant chemotherapy; HR=hazard ratio; LG=low-grade; HG=high-grade;
PUNLMP=papillary urothelial neoplasm of low malignant potential; NS=non-significant.
Bold
: statistically significant relationship.
*
Former vs. never smokers.
y
Current vs. never smokers.
z
Current vs. former vs. never smokers.
§
Quitters vs. former smokers.
k
Current vs. former smokers.
Never smokers vs. quitters.
**
Former smokers vs. quitters.
yy
Current smokers vs. quitters.
zz
20-39 vs. 1-19 pack-years.
§§
40-59 vs. 1-19 pack-years.
kk
60 vs. 1-19 pack-years.
Smokers vs. non-smokers.
***
Number of cigarettes per day.
yyy
Number of years of smoking.
zzz
Number of pack-years.
§§§
20 vs.
<
20 cigarettes per day.
kkk
20 vs.
<
20 years of smoking.
Moderate vs. light short-term smokers.
****
Heavy long-term (
>
20 cigarettes per day for
>
20 years) vs. light short-term ( 20 cigarettes per day for 20 years) smokers.
yyyy
Heavy long-term vs. moderate (
>
20 cigarettes per day for 20 years or 20 cigarettes per day for
>
20 years) vs. light short-term smokers.
zzzz
Heavy short-term (
>
20 cigarettes per day for 20 years) vs. heavy long-term smokers.
§§§§
Light long-term ( 20 cigarettes per day for
>
20 years) vs. heavy long-term smokers.
kkkk
Light short-term vs. heavy long-term smokers.
E U R O P E A N
U R O L O G Y
F O C U S
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